Hedgehog signaling pathway
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The Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, prevents inhibition of a 7 transmembrane receptor called Smoothened. This leads to activation of GLI family of transcription factors (GLI1-3). Signaling through the Hedgehog pathway is essential for development of many tissues and organs. This pathway is highly conserved among metazoans. Aberrant activation of this pathway has been associated with a number of human malignancies including carcinoma of lung, esophagus, pancreas and prostate. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_10
刺猬蛋白家族是一类分泌型配体，包括人类中的 Sonic hedgehog、Indian hedgehog 和 Desert hedgehog。刺猬蛋白配体与其受体 Patched 1 和 2 的结合，能够阻止对具有 7 个跨膜结构的受体 Smoothened 的抑制。这一过程进而导致 GLI 家族转录因子（GLI1-3）的激活。Hedgehog 信号通路在众多组织和器官的发育过程中发挥着至关重要的作用，该通路在多细胞生物中高度保守。该通路的异常激活与多种人类恶性肿瘤的发生密切相关，包括肺癌、食管癌、胰腺癌和前列腺癌。来源：NetPath http://www.netpath.org/pathways?path_id=NetPath_10
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