Descriptions of included studies (all conducted and analyzed as cohort studies).

*discontinuation of initial antipsychotic or initiation of comparator antipsychotic.†SAGE: Systematic Assessment of Geriatric Drug Use via Epidemiology database.‡MDS: Minimum Dataset baseline and follow-up clinical assessments.§OSCAR: Online Survey, Certification and Reporting for U.S.**This estimate for was for the community-dwelling cohort; the corresponding estimate for the long-term care cohort was RD = 2.2 (95%CI 0.0 to 4.4). We took a weighted average of these estimates according to the reported distribution of community-dwelling and long-term care residents and obtained a point estimate of RD = 2.47%.***Rate among persons 70 to 74 years of age.