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Human and insect cell-produced rAAVs show differences in ITR heterogeneity and content in empty particles. Adeno Associated Virus (AAV)

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NIAID Data Ecosystem2026-03-13 收录
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AAV-GPseq analyses reveal that AAV vectors produced by the HEK293 human cell platform and the Sf9 insect cell-baculovirus platform show differences in genome heterogeneity and packaging of short DNA fragments in particles that are attributed to a high degree of unresolved ITRs in packaged virions.

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2021-12-19
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