Bilateral Ovarian Malignant Brenner Tumour : A Case Report With Literature Review

Brenner
tumor of the ovary is very rare, mostly benign, small, and unilateral.
Malignant brenner tumor (MBT) is much rarer. We present a patient aged 50
years, with no specific pathological history who presented in consultation for
chronic pelvic pain. Pelvic ultrasound demonstrated a bilateral latero-uterine
mass of suspicious appearance with local infiltration with peritoneal
carcinosis and an ascites of average abundance. The pathological examination had
concluded in a bilateral brenner tumor, endometrium, omentum are all invaded.
Brenner tumors are rare ovarian tumors, first described by McNaughton-Jones in
1898 and then named by Frits Brenner in 1907. MBT presents similarly to other
ovarian cancers (abdominal distension, abdominal pain, bulk symptoms and
relative vague symptomatology).All histopathological diagnoses were performed
according to the criteria described by Hull and Campbell. Tumors express
several immunohistochemical markers of urothelial differentiation including
uroplakin III, thrombomodulin, GATA3, p63, as well as cytokeratin 7. The
primary treatment modality is surgical excision. This study discussed the
clinical, pathological characteristics and treatment of MBTs