The SIR complex (Silent Information Regulator) is the building block of heterochromatic structures that silence underlying genes. It is well established that the silenced state is epigenetically inher
Prior to the initiation of DNA synthesis, ORC and Cdc6 load the MCM helicase at all replication origins. However, when MCM loading is compromised (e.g., as in the temperature-sensitive cdc6-4 mutant)
