Ugonin inhibits chondrosarcoma metastasis through suppressing cathepsin V via promoting miR-4799-5p expression

Chondrosarcoma is a rare type of bone cancer that develops in cartilage cells. Ugonin V is a flavonoid compound that has been extracted from the plant Helminthostachys zeylanica (L.) Hook. This study examined the molecular therapeutic effects of ugonin V on chondrosarcoma metastasis. To identify differentially expressed miRNAs regulated by Ugonin V, JJ012 cells were treated with Ugonin V (10 μM) for 24 h in the culture medium, and miRNA sequencing was performed.