Supplementary data sets for the PNAS Nexus 2023 manuscript by Xiaokang et al

Wild_Type includes data for the wild type (WT) system with all three methyltransferases (G9a, SETDB1 and SUV39H1/2) present at 100% concentration
SETDB1_75: SetDB1 knocked down to a 75% concentration (with respect to WT)
SETDB1_50: SetDB1 knocked down to a 50% concentration
G9A_75: G9A knocked down to a 75% concentration
G9A_50: G9A knocked down to a 50% concentration
SUV_75: Suv39h knocked down to a 75% concentration
SUV_50: Suv39h knocked down to a 50% concentration

Rows contain data for the respective time steps
Columns contain data for the respective H3K9 methylation states (0 = H3K9me0, 1 = H3K9me1, 2 = H3K9me2, and 3 = H3K9me3)

For the ensemble averages, the rows represent time and the columns the abundance of each methylation state:
(Column 1 is H3K9me0, Column 2 = H3K9me1, Column 3 = H3K9me2, and Column 4 = H3K9me3)
As a note, H3K9me0 column starts at 100 and the H3K9me3 column starts at 2 due to the two pre methylated ones.

Wild_Type 数据集包含野生型（WT）系统中所有三种甲基转移酶（G9a、SETDB1及SUV39H1/2）均以100%浓度存在的数据。
SETDB1_75：SetDB1 表达下调至75%浓度（相对于WT）。
SETDB1_50：SetDB1 表达下调至50%浓度。
G9A_75：G9A 表达下调至75%浓度。
G9A_50：G9A 表达下调至50%浓度。
SUV_75：Suv39h 表达下调至75%浓度。
SUV_50：Suv39h 表达下调至50%浓度。
数据行包含相应时间步长的数据，数据列包含相应H3K9甲基化状态的数据（0 = H3K9me0，1 = H3K9me1，2 = H3K9me2，以及3 = H3K9me3）。
对于集成平均值，数据行代表时间，数据列代表每种甲基化状态的含量：（列1为H3K9me0，列2 = H3K9me1，列3 = H3K9me2，列4 = H3K9me3）。
备注：由于存在两个预先甲基化的位点，H3K9me0列起始值为100，而H3K9me3列起始值为2。