Examples of proteins with putative high bi-stability.

Proteins are ordered by increasing stability difference (decreasing bi-stability) and they may be classified into the following functional categories: metabolism (Purine-nucleoside phosphorylase, Camphor 5-monooxygenase, Glycogen phosphorylase, Adenylate kinase, Hydrolase, Cytochrome P450 119, Light-harvesting protein B-875 beta chain), transcriptional regulation (HTH-type transcriptional regulator qacR, Regulatory protein rop), epigenetic regulation (Histone-lysine N-methyltransferase, Chromobox protein homolog 1), signalling (Synapsin-2, Protein enhancer of sevenless 2B, Baculoviral IAP repeat-containing protein 4, Antithrombin-III, Lymphotactin), translation (50S ribosomal protein L11), cytoskeleton (Talin-1, Synapsin-2), and host-pathogen interaction/immune system (Ig epsilon chain C region, Nitrophorin-4, Baculoviral IAP repeat-containing protein 4, Lymphotactin, Capsid protein G8P).aCATH [64] structural domain identifiers.bRoot Mean Square Deviation of backbone atoms; in units of Å.cRosetta standard free energy score/domain length.