Effects of intolerance of uncertainty on subjective and psychophysiological measures during threat acquisition and delayed threat extinction

This dataset includes measurements of intolerance of uncertainty (Intolerance of Uncertainty Scale [Freeston et al., 1994]), trait anxiety (State-Trait Anxiety Inventory [Spielberger et al., 1983]), skin conductance response (SCR), fear potentiated startle (FPS) and fear ratings (RAT) acquired in a differential fear conditioning paradigm with habituation and threat acquisition training on one day and extinction training, mood induction (by presenting negative vs. neutral slides), re-extinction training, reinstatement and reinstatement-test 24h later. Overall, 66 participants (female = 44, aged between 18 and 40 years, M = 25.76, SD = 5.82) took part in the study. Several participants had to be excluded due to technical issues (n = 3), non-responding (SCR: n = 2; auditory startle blink: n = 1) and no SCRs to the CSs (n = 1). Visual CSs were two shapes resembling snowflakes. The US consisted of a train of three 2 ms electrotactile square-waves (inter stimulus interval, ISI: 50 ms) and was delivered 7.9 s after each CS+ onset (100% reinforcement rate) during threat acquisition training and three times during reinstatement. The duration of the ITIs ranged from 10 to 13 s (M = 11.5). For SCR measurements, a 1 Hz lowpass filter and a gain of 5 or 10 μΩ were applied. SCR data were scored by using the semi-automatic scoring system Autonomate (Green et al., 2014), down sampled to 10 Hz and scored as the first response within 0.9 to 4 s after CS onset as SCR from trough to peak with a maximum rise time of 5 s. SCRs were square root transformed to reduce skew and z-scored within individuals across trials for day 1 and day 2 separately. To elicit the auditory startle blink, a 95 dB white noise burst was presented simultaneously on both ears. Startle probes were administered 6 or 8 s after the ITI-onset and 6 or 7 s after CS-onset. A gain of 5000 at 1000 Hz and a band-pass filter (28–500 Hz) were applied. Data were rectified and integrated online (averaged over 20 samples) and scored semi-automatically by using a custom-made computer program (EDA View, developed by Prof. Dr. Matthias Gamer, University of Würzburg) as trough to peak 20–120 ms after startle probe onset. For analyses, FPS data was z-scored within individuals across trials for day 1 and day 2 separately. To acquire fear ratings, participants rated throughout the experiment, how much stress, fear, and tension they experienced, when they last saw the CSs. Answers had to be logged in via button press within 7 s on a visual analog scale (VAS) ranging from zero (answer = none) to 100 (answer = maximum). Unlogged ratings were considered as missing values.本数据集包含以下测量指标：不确定性容忍度量表（Intolerance of Uncertainty Scale，Freeston et al., 1994）、状态-特质焦虑问卷（State-Trait Anxiety Inventory，Spielberger et al., 1983）、皮肤电反应（skin conductance response, SCR）、恐惧增强惊反射（fear potentiated startle, FPS）以及恐惧评定（fear ratings, RAT）。上述指标均采自差别恐惧条件化范式实验，实验流程分为单日的习惯化与威胁习得训练，后续依次开展消退训练、情绪诱导（通过呈现负性与中性幻灯片）、再消退训练、恢复效应实验以及24小时后的恢复测试。 本研究共招募66名参与者（女性44名，年龄18至40岁，平均年龄M=25.76，标准差SD=5.82）。因技术故障（n=3）、无有效反应（皮肤电反应无响应：n=2；听觉惊跳眨眼无响应：n=1）以及对条件刺激无皮肤电反应（n=1），共排除7名参与者。 视觉条件刺激（CSs）为两种形似雪花的图形。非条件刺激（unconditioned stimulus, US）为一串3个2ms的电触方形波，刺激间间隔（inter stimulus interval, ISI）为50ms。在威胁习得训练阶段，每一次条件刺激阳性（CS+）起始后7.9s施加US，强化率为100%；在恢复效应阶段共施加3次US。试间间隔（inter-trial intervals, ITIs）时长为10至13s，平均时长M=11.5s。 皮肤电反应测量环节采用1Hz低通滤波器，增益设置为5或10μΩ。SCR数据通过半自动评分系统Autonomate（Green et al., 2014）进行评分，随后下采样至10Hz，以条件刺激起始后0.9至4s内的首个反应作为SCR指标，计算从波谷到波峰的幅值，且上升时长最大为5s。为降低数据偏态，对SCR数据进行平方根转换，并分别在第1天和第2天的试验内对每名参与者的数据进行Z分数标准化。 为诱发听觉惊跳眨眼反射，向双耳同步呈现95dB的白噪音脉冲。惊反射刺激探针于试间间隔起始后6或8s、条件刺激起始后6或7s时施加。信号处理环节采用1000Hz下增益5000的设置以及28至500Hz的带通滤波器，数据经在线整流与积分（对20个采样点取平均）后，通过定制计算机程序EDA View（由德国维尔茨堡大学Matthias Gamer教授开发）进行半自动评分，以惊反射刺激探针起始后20至120ms内的波谷至波峰幅值作为指标。数据分析时，同样分别在第1天和第2天的试验内对每名参与者的FPS数据进行Z分数标准化。 恐惧评定环节要求参与者在整个实验过程中，针对最后一次接触的条件刺激，报告自身感受到的压力、恐惧与紧张程度。被试需在7s内通过按键在视觉模拟量表（visual analog scale, VAS）上作答，量表值域为0（无任何感受）至100（感受达到最大）。未及时记录的评定结果视为缺失值。