Immunoreactivity and Molecular Dynamics of arginine kinase wild type from tick Rhipicephalus sanguineus and a mutant E1

The brown dog tick Rhipicephalus sanguineus is a significant vector for Rocky Mountain Spotted Fever (RMSF), a disease caused by Rickettsia rickettsii. We report a data on the effect of the tick bite on the immune response in humans of arginine kinase wild type (WT) from tick Rhipicephalus sanguineus and a mutant E1. Absorbance values obtained by ELISA, Calculation of INDEX Value and statistical analysis data is showed. Furthermore, predictions of WT and E1 RsAK structures were conducted using ColabFold v1.5.2 software. The impact of the mutation on conformational stability was evaluated through molecular dynamics (MD) simulations.

血红扇头蜱（Rhipicephalus sanguineus）是落基山斑疹热（Rocky Mountain Spotted Fever，RMSF）的重要传播媒介，该疾病由立克次氏立克次体（Rickettsia rickettsii）引发。本数据集收录了蜱源血红扇头蜱精氨酸激酶（arginine kinase）野生型（wild type，WT）及其突变体E1在蜱叮咬后对人体免疫反应影响的相关数据，包含酶联免疫吸附测定（Enzyme-Linked Immunosorbent Assay，ELISA）所得吸光度值、指数值计算结果与统计分析数据。此外，本研究使用ColabFold v1.5.2软件对WT及E1型RsAK的结构进行了预测，并通过分子动力学（molecular dynamics，MD）模拟评估了该突变对蛋白质构象稳定性的影响。