Glyceryl guaiacol ether for sedation of horses undergoing orchiectomy when standing

ABSTRACT A study was designed to compare two sedation protocols to be used in horses undergoing orchiectomy when standing. In both protocols, the induction to the sedative state was performed with bolus detomidine at a dose of 10 µg/kg, intravenously (IV). In the first protocol (eight horses), the sedative state was maintained with 1% glyceryl guaiacol ether (GGE) in continuous infusion, at a dose of 1ml/kg/hour IV. In the second protocol (eight horses) this sedative effect was maintained with detomidine in continuous infusion at the same dose and induction route. Orchiectomy was performed on all animals. The two protocols allowed the surgeries to be performed when standing. However, horses kept under sedation by the GGE showed greater relaxation and a more intense degree of sedation. It should be noted that the use of GGE to maintain the sedative state in horses is unprecedented in the literature. The drug is used in anesthetic protocols in the species, but only in pre-anesthetic medication in general anesthesia. It was concluded that the two sedation protocols allowed the performance of orchiectomy with the horses when standing. However, the protocol in which 1% GGE was used showed more profound sedation, without adverse effects.

摘要 本研究旨在对比两种用于站立式马睾丸摘除术（orchiectomy）的镇静方案。两种方案的镇静诱导阶段均采用静脉推注右美托咪定，给药剂量为10 μg/kg，给药途径为静脉内（IV）。方案一（8匹受试马）采用1%愈创甘油醚（glyceryl guaiacol ether, GGE）持续静脉输注以维持镇静状态，输注剂量为1 ml/kg/h。方案二（8匹受试马）则以相同给药剂量与途径持续输注右美托咪定以维持镇静效果。所有受试动物均施行了睾丸摘除术。两种方案均可支持站立式手术的顺利实施。然而，采用愈创甘油醚（GGE）维持镇静的受试马匹展现出更优异的肌肉松弛效果与更深程度的镇静状态。需特别指出，当前学术文献中尚未见使用愈创甘油醚（GGE）维持马镇静状态的报道；该药物虽已应用于该物种的麻醉方案，但仅作为全身麻醉的术前用药使用。本研究得出结论：两种镇静方案均可顺利完成站立式马睾丸摘除术，其中采用1%愈创甘油醚（GGE）的方案可实现更深程度的镇静效果，且未出现不良反应。