CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH BISUBSTRATE INHIBITOR (TP5A)

CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH BISUBSTRATE INHIBITOR (TP5A) Descriptor: MAGNESIUM ION, P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, SULFATE ION, ... Authors: Haouz, A, Vanheusden, V, Munier-Lehmann, H, Froeyen, M, Herdewijn, P, Van Calenbergh, S, Delarue, M. Deposit date: 2002-09-18 Release date: 2003-01-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism. J.Biol.Chem., 278, 2003

结核分枝杆菌胸苷酸激酶与双底物抑制剂（TP5A）结合的晶体结构。复合物组分：镁离子、P1-(5'-腺苷基)P5-(5'-胸苷基)五磷酸、硫酸根离子……。作者：Haouz, A、Vanheusden, V、Munier-Lehmann, H、Froeyen, M、Herdewijn, P、Van Calenbergh, S、Delarue, M。沉积日期：2002-09-18；发布日期：2003-01-07；最后修改日期：2024-02-14。实验方法：X射线衍射（分辨率2.45埃）。引用文献：《抗结核分枝杆菌胸苷酸激酶抑制剂的酶学与结构分析：磷酸转移机制的新见解》，《生物化学杂志》，2003年，第278卷。