Filicinic Acid Based Meroterpenoids with Anti-Epstein–Barr Virus Activities from Hypericum japonicum

Seven filicinic acid–based
meroterpenoids (1–7), possessing
6/6/11, 6/6/7/5, or 6/6/10 ring
systems, were isolated from Hypericum japonicum.
All of them have novel skeletons with the incorporation of sesquiterpenoid
moieties to an acylated filicinic acid. Compounds 2a and 4 exhibited significant efficacy on anti-Epstein–Barr
virus, with EC50 values of 0.57 and 0.49 μM, respectively.
Furthermore, compounds 2a and 4 were well
accommodated to the binding pocket of 2GV9 predicted by the molecular
docking.

从日本金丝桃（Hypericum japonicum）中分离出七种基于菲尼酸（filicinic acid）的甲氧基萜类化合物（1-7），它们分别具有6/6/11、6/6/7/5或6/6/10的环状结构系统。这些化合物均拥有新颖的骨架结构，通过将倍半萜单元并入酰化菲尼酸中实现。其中，化合物2a和4在抗爱泼斯坦-巴尔病毒（Epstein–Barr virus）方面表现出显著的活性，其半数有效浓度（EC50）分别为0.57和0.49微摩尔。此外，2a和4化合物与通过分子对接预测的2GV9结合口袋具有良好的适配性。