Ras guanine exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C) and fragment screening hit F2

Ras guanine exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C) and fragment screening hit F2 Descriptor: 1-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-2-oxidanyl-ethanone, DIMETHYL SULFOXIDE, GLYCEROL, ... Authors: Hillig, R.C, Moosmayer, D, Hilpmann, A, Bader, B, Schroeder, J, Wortmann, L, Sautier, B, Kahmann, J, Wegener, D, Briem, H, Petersen, K, Badock, V. Deposit date: 2017-10-12 Release date: 2019-02-06 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc. Natl. Acad. Sci. U.S.A., 116, 2019

与KRAS(G12C)及片段筛选命中化合物F2结合的Ras鸟苷酸交换因子SOS1（Rem-cdc25）。配体描述：1-(3,4-二氢-1H-异喹啉-2-基)-2-羟基乙酮、二甲基亚砜、甘油等。作者：Hillig, R.C.、Moosmayer, D.、Hilpmann, A.、Bader, B.、Schroeder, J.、Wortmann, L.、Sautier, B.、Kahmann, J.、Wegener, D.、Briem, H.、Petersen, K.、Badock, V.。提交日期：2017-10-12；发布日期：2019-02-06；最后修改日期：2024-01-17。实验方法：X射线衍射（分辨率2.5 Å）。引用：《通过破坏RAS-SOS1相互作用阻断RAS激活的强效SOS1抑制剂的发现》，《美国国家科学院院刊》，116卷，2019年。