Crystal structure of okaE in complex with a-ketoglutarate and okaramine A at 2.5 angstroms resolution.

Crystal structure of okaE in complex with a-ketoglutarate and okaramine A at 2.5 angstroms resolution. Descriptor: (1Z,4R,12S,14S,17Z)-12-hydroxy-19,19-dimethyl-5-(2-methylbut-3-en-2-yl)-3,5,16,21-tetrazaheptacyclo[14.13.0.03,14.04,12.06,11.020,28.022,27]nonacosa-1(29),6,8,10,17,20(28),22,24,26-nonaene-2,15-dione, 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent dioxygenase, ... Authors: Liu, T.H, Yan, W.P. Deposit date: 2025-02-27 Release date: 2026-03-04 Last modified: 2026-04-08 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural and mechanistic insights into azetidine-associated alpha KG-NHFe enzyme OkaE with multifunctional catalysis. Nat Commun, 17, 2026分辨率为2.5埃的okaE与α-酮戊二酸（α-ketoglutarate）和奥卡霉素A（okaramine A）复合物的晶体结构。 描述符：(1Z,4R,12S,14S,17Z)-12-羟基-19,19-二甲基-5-(2-甲基丁-3-烯-2-基)-3,5,16,21-四氮杂七环[14.13.0.0³,¹⁴.0⁴,¹².0⁶,¹¹.0²⁰,²⁸.0²²,²⁷]二十九碳-1(29),6,8,10,17,20(28),22,24,26-壬烯-2,15-二酮、2-氧代戊二酸、α-酮戊二酸依赖性双加氧酶…… 作者：Liu, T.H.、Yan, W.P. 提交日期：2025-02-27 发布日期：2026-03-04 最后修改日期：2026-04-08 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.55埃 引用文献：《兼具多功能催化活性的氮杂环丁烷关联αKG-NHFe酶OkaE的结构与机制解析》，《自然-通讯》（Nat Commun），第17卷，2026年