Drug therapies and their efficacy scores.

Drug therapies were simulated with their molecular targets and the drug-specific scores computed for each scenario. The overall score is the sum of the previous scores and serves as a general performance indicator. The scoring formula is explained in Materials and Methods. Each score in the specific scenarios is from -4 to 4 and considers the advantages of the cell in terms of enrichment of the favorable phenotypes or reduction of the unfavorable ones. The overall score has a minimum and a maximum, respectively, of -12 and 12. Drugs are sorted according to the overall score to highlight those that are predicted to perform better.