Raw and processed in vitro release (IVRT) data for "A modelling-based comparison of IVRT and synthetic-membrane permeation for early formulation screening"

This dataset contains the raw and processed in vitro release test (IVRT) data underlying Table 1 and Figure 1 of the article "A modelling-based comparison of IVRT and synthetic-membrane permeation for early formulation screening" (RSC Pharmaceutics, DOI: 10.1039/d6pm00035e). Fifteen ibuprofen / poloxamer-407 gel formulations (F1–F15) were tested by IVRT on a nylon membrane over 6 h with UV–Vis quantification. The archive contains:- 01_UV_absorbance_raw.xlsx — raw UV–Vis absorbance readings and the wavelength-derived concentrations for every sample;- 02_UV_calibration.xlsx — ibuprofen calibration standards and wavelength-specific calibration curves;- 03_per_formulation_processed.xlsx — per-formulation (F1–F15), per-replicate cumulative release and the means/SDs reported in Table 1;- README.md — full file descriptions and analytical conventions. The corresponding in vitro permeation test (IVPT) data are reported in a previous publication (Int. J. Pharm., 2025, 125306; DOI: 10.1016/j.ijpharm.2025.125306).本数据集收录了发表于论文《基于模型的体外释放试验与合成膜渗透法早期制剂筛选对比》（A modelling-based comparison of IVRT and synthetic-membrane permeation for early formulation screening）（刊载于RSC Pharmaceutics，DOI: 10.1039/d6pm00035e）中表1与图1所依托的原始及处理后人体外释放试验（in vitro release test, IVRT）数据。 研究团队针对15种布洛芬/泊洛沙姆-407凝胶制剂（F1–F15）开展了尼龙膜载体的6小时IVRT试验，并通过紫外-可见分光光度法（UV–Vis）完成定量检测。该数据集的归档文件包含： - 01_UV_absorbance_raw.xlsx：所有受试样品的原始紫外-可见吸光度读数，以及基于波长推导得到的对应浓度数据； - 02_UV_calibration.xlsx：布洛芬校准标准品信息与对应波长的校准曲线数据； - 03_per_formulation_processed.xlsx：各制剂（F1–F15）的平行样累积释放量，以及表1中所报告的均值与标准差（standard deviation, SD）； - README.md：完整的文件说明与分析操作规范。 与之对应的体外渗透试验（in vitro permeation test, IVPT）数据已发表于此前的研究成果（Int. J. Pharm., 2025, 125306; DOI: 10.1016/j.ijpharm.2025.125306）。