TLR4 in Breast Cancer

Breast cancer (BC) is heterogeneous in clinical manifestation, of which the triple negative (TNBC) subtype is the most aggressive. This study examines the associations between Toll-Like Receptor (TLR)-4 polymorphisms and the susceptibility to BC and TNBC. Genotyping of TLR-4 rs2770150, rs2149356, rs1554973 and rs7856729 polymorphisms was done by real-time PCR in 488 women with BC (130 TNBC, 358 non-TNBC), and 476 cancer-free control women.

乳腺癌（Breast cancer, BC）临床表现具有异质性，其中三阴性乳腺癌（triple negative, TNBC）亚型的侵袭性最强。本研究旨在探讨Toll样受体（Toll-Like Receptor, TLR）-4基因多态性与乳腺癌及三阴性乳腺癌的易感性之间的关联。本研究纳入488名乳腺癌患者（含130例三阴性乳腺癌患者、358例非三阴性乳腺癌患者）与476名健康女性对照，通过实时荧光定量PCR（real-time PCR）完成了TLR-4基因rs2770150、rs2149356、rs1554973及rs7856729位点多态性的基因分型检测。