Lifelines NEXT gut (LLNEXT-GV) and breastmilk (LLNEXT-BMV) viral catalogs
收藏资源简介：
The Lifelines NEXT gut (LLNEXT-GV) and breastmilk (LLNEXT-BMV) viral catalogs comprise representative viral genomes (vOTUs) and their associated metadata, recovered from 4,523 fecal and 91 breastmilk metagenomes collected from 714 mother–infant pairs in the Dutch Lifelines NEXT birth cohort. These genomes were integrated with data from ten additional independent studies and/or resources and annotated using a standardized bioinformatics pipeline. Separate files are provided for the LLNEXT-derived vOTU representatives and the full set of deduplicated viral genomes generated exclusively from the Lifelines NEXT dataset. File Description LLNEXT_GV_catalog.fa.gz LLNEXT-GV vOTU representative viral genomes (n=31,019) LLNEXT_GV_catalog_metadata.tsv Metadata for all LLNEXT-GV species-level vOTUs LLNEXT_gut_viral_abundance_table.tsv Per-sample RPKM abundances of LLNEXT-GV vOTUs derived from read mapping LLNEXT_only_gut_vOTU_representatives.fa.gz LLNEXT gut vOTU representative genomes (excluding external DBs) (n=27,299) LLNEXT_only_gut_vOTU_all_genomes.fa.gz LLNEXT gut viral genomes after deduplication (excluding external DBs) (n=56,197) LLNEXT_BMV_catalog.fa.gz LLNEXT-BMV representative viral genomes (breastmilk) (n=248) LLNEXT_BMV_catalog_metadata.tsv Metadata for all LLNEXT-BMV species-level vOTUs
Lifelines NEXT肠道（LLNEXT-GV）与母乳（LLNEXT-BMV）病毒目录包含代表性病毒操作分类单元（viral Operational Taxonomic Unit，vOTU）基因组及其关联元数据，这些序列均从荷兰Lifelines NEXT出生队列的714对母婴的4523份粪便样本与91份母乳宏基因组中组装恢复得到。本研究将上述基因组与另外10项独立研究及/或数据库资源的数据进行整合，并通过标准化生物信息学分析流程完成注释。数据集分别提供了LLNEXT衍生的vOTU代表序列，以及仅基于Lifelines NEXT数据集生成的全套去重后病毒基因组文件。 文件 | 描述 LLNEXT_GV_catalog.fa.gz | LLNEXT-GV vOTU代表病毒基因组（n=31,019） LLNEXT_GV_catalog_metadata.tsv | 所有LLNEXT-GV物种级vOTU的元数据 LLNEXT_gut_viral_abundance_table.tsv | 基于读段比对得到的LLNEXT-GV vOTU单样本RPKM丰度表 LLNEXT_only_gut_vOTU_representatives.fa.gz | 仅来自Lifelines NEXT肠道数据集的vOTU代表基因组（不含外部数据库序列）（n=27,299） LLNEXT_only_gut_vOTU_all_genomes.fa.gz | 去重后的Lifelines NEXT肠道全套病毒基因组（不含外部数据库序列）（n=56,197） LLNEXT_BMV_catalog.fa.gz | LLNEXT-BMV母乳来源代表性病毒基因组（n=248） LLNEXT_BMV_catalog_metadata.tsv | 所有LLNEXT-BMV物种级vOTU的元数据
