Catalan et al.Supplemental Material.AJP.25.pdf
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资源简介：
AE4 is a HCO<sub>3</sub><sup>-</sup> transporter that is important for electrolyte transport and pH regulation in epithelia, which has been proposed to mediate Cl<sup>-</sup>/cation-HCO<sub>3</sub><sup>-</sup> exchange. However, critical residues sustaining transport activity are not known. In this study, we show that AE4 is able to coordinate HCO<sub>3</sub><sup>-</sup> and Na<sup>+</sup> or K<sup>+</sup> at the TM3-TM10 interface, and that residues T448 and T756 are crucial for cation binding and transport cycle.
提供机构：
Peña-Münzenmayer, Gaspar; A. Catalán, Marcelo; Kurtz, Ira; Fernández, Fernanda; Gonzalez, Wendy; Zúñiga, Leandro; Sarmiento, José; Apablaza, Natalia; Kao, Li Yo; Mazola, Yuliet; Matamala, Ella; Spichiger, Carlos; Bustos, Daniel; Flores-Aldama, Lisandra; Brauchi, Sebastián; Hidalgo, Ailen
创建时间：
2025-05-22
