Solithromycin mitigates Prevotella intermedia–induced exacerbation of MRSA ventilator-associated pneumonia by modulating hyperinflammatory responses and enhancing alveolar macrophage function

Solithromycin protects by activating alveolar macrophages and promoting TNF-related responses, suggesting a novel immunomodulatory role for solithromycin in host defense against exacerbation of MRSA-VAP by P. int. sup. In vitro, total RNA was extracted from the lungs infected with MRSA in the presence of P. int. sup. or P. int. sup. (SOL) at 12 h post-infection in mice