GSE32518 Expression Data

Expression data from paired matched breast cancer Fine needle aspiration (FNA) or Core needle biopsies (CBX). Paired FNA and CBX specimens were prospectively collected from 37 breast cancers before any systemic therapy during a biomarker discovery study at The University of Texas M. D. Anderson Cancer Center.We identified 293 probe sets overexpressed in core biopsies; these included five highly coexpressed gene clusters (metagenes) corresponding to immune functions and extracellular matrix components.We compared gene expression profiles of pairs of fine-needle (stroma-poor) and core-needle (stroma-rich) biopsies from 37 cancers to identify stroma-associated genes.本数据集包含配对匹配的乳腺癌细针抽吸活检（Fine Needle Aspiration, FNA）与核心针活检（Core Needle Biopsies, CBX）的基因表达数据。 本研究为德克萨斯大学MD安德森癌症中心开展的生物标志物发现研究，共前瞻性收集了37例未接受任何全身治疗的乳腺癌患者的配对FNA与CBX标本。研究人员在核心活检标本中鉴定出293个过表达的探针集，其中包含5个与免疫功能及细胞外基质成分相关的高度共表达基因簇（元基因，metagenes）。研究人员比对了37例乳腺癌的细针（基质贫乏型）与核心针（基质丰富型）活检标本的基因表达谱，以筛选基质相关基因。