MS-BCR-DB: an integrated BCR repertoire database to mine humoral multiple sclerosis signatures

The MS-BCR-Database, it's an harmonized collection of publicly available human MS BCR-sequencing datasets processed using a standardized pipeline and organized in an AIRR-compliant format. This database integrates 11 independent MS BCR-sequencing studies comprising: 114 MS patients 5,368,636 BCR sequences Samples from multiple tissues including cerebrospinal fluid and peripheral blood Both bulk and single-cell sequencing datasets Related publicationA detailed description of the database and its biological analyses is provided in the associated preprint: DOI: https://doi.org/10.64898/2026.03.05.709606 Data provenanceAll sequences originate from previously published and publicly available datasets. Original study references are included in the accompanying documentation.MS-BCR数据库（MS-BCR-Database）是一套经标准化流程处理、采用AIRR兼容格式（AIRR-compliant format）组织的公开人类多发性硬化（Multiple Sclerosis，MS）B细胞受体（B Cell Receptor，BCR）测序数据集的统一整合合集。 本数据库整合了11项独立的多发性硬化B细胞受体测序研究，涵盖以下内容： 1. 114名多发性硬化患者 2. 5,368,636条B细胞受体测序序列 3. 包含脑脊液与外周血在内的多组织来源样本 4. 批量测序与单细胞测序两类数据集 相关研究文献：本数据库及其生物学分析的详细描述已在关联预印本中发布，DOI：https://doi.org/10.64898/2026.03.05.709606 数据来源：所有测序序列均来自已发表的公开数据集，原始研究的参考文献已收录于随附文档中。