Data underlying the research of Changes in gut microbiota and metabolites in patients with Perioperative Neurocognitive Disorder

Perioperative neurocognitive disorder (PND), as a topic of common concern in anesthesia, neuropsychiatry and geriatrics, has been the subject of a wave of research at home and abroad. Patients are focusing more attention on postoperative regression while paying attention to the damage of surgery to the body, which makes the research on brain protection more fruitful. Although there have been a large number of results on postoperative cognition, brain protection starting from the direction of gut microbiota disruption has not yet matured. In this study, we collected fecal samples from surgical patients to examine the abundance and diversity of gut microbiota, and screened different microbiomes and metabolites from samples of PND and performed microbiomics and metabolomics correlation analyses to analyze the correlation between gut microbiota and PND from the perspective of multi-omics and to predict the possible signaling and met albolism pathways, which can be used to provide references for the clinical diagnosis and treatment of PND.