Total Synthesis of Celastrol, Development of a Platform to Access Celastroid Natural Products
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https://figshare.com/articles/dataset/Total_Synthesis_of_Celastrol_Development_of_a_Platform_to_Access_Celastroid_Natural_Products/2128705
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资源简介：
Celastroid
natural products, triterpenes, have been and continue
to be investigated in clinical trials. Celastrol, and for that matter
any member of the celastroid family, was prepared for the first time
through chemical synthesis starting from 2,3-dimethylbutadiene. A
triene cyclization precursor generated in 12 steps underwent a nonbiomimetic
polyene cyclization mediated by ferric chloride to generate the generic
celastroid pentacyclic core. In the cyclization, engagement of a tetrasubstituted
olefin formed adjacent all carbon quaternary centers stereospecifically.
With access to the carbocyclic core of the family of natural products,
wilforic acid and wilforol A were prepared en route to racemic celastrol.
创建时间：
2016-02-13
