X-ray structure of the complex between human alpha-thrombin and modified 15-mer DNA aptamer containing 5-(3-(acetamide-N-yl)-1-propen-1-yl)-2'-deoxyuridine residue

X-ray structure of the complex between human alpha-thrombin and modified 15-mer DNA aptamer containing 5-(3-(acetamide-N-yl)-1-propen-1-yl)-2'-deoxyuridine residue Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, GA68B2 - MODIFIED HUMAN THROMBIN BINDING APTAMER, ... Authors: Dolot, R.M, Nawrot, B, Yang, X. Deposit date: 2017-10-09 Release date: 2017-10-18 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity. Nucleic Acids Res., 46, 2018

人α-凝血酶（human alpha-thrombin）与含5-(3-(乙酰胺-N-基)-1-丙烯-1-基)-2'-脱氧尿苷残基的修饰型15聚体DNA适配体（DNA aptamer）形成的复合物的X射线晶体结构。描述项：2-乙酰胺-2-脱氧-β-D-吡喃葡萄糖、D-苯丙氨酰-N-[(2S,3S)-6-{[氨基(亚氨基甲基)]氨基}-1-氯-2-羟基己烷-3-基]-L-脯氨酰胺、GA68B2——修饰型人凝血酶结合适配体，……作者：Dolot, R.M.、Nawrot, B.、Yang, X.。入库日期：2017-10-09；发布日期：2017-10-18；最后修改时间：2024-11-13。实验方法：X射线衍射（2.24埃）。引用文献：《与化学修饰凝血酶DNA适配体结合的凝血酶晶体结构揭示亲和力增强的根源》，《核酸研究（Nucleic Acids Res.）》，第46卷，2018年