Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function

We used bulk and single-cell ATAC-seq to measure chromatin accessibilty in human kidneys. This allowed us to define candidate cis-regulatory elements of each human kidney cell type and identify the role of podocyte and tubule regulatory elements in human kidney function. Overall design: Single cell ATAC-sequencing of 3 human kidneys. Single cell ATAC-sequencing was performed on cortex from all 3 kidneys and medulla from two of the kidneys. Bulk ATAC-sequencing from the cortex of one human kidney was also performed. **Please note that the records have been updated with additional data on Aug 8, 2024.****