Loss of ESRP1 blocks mouse oocyte development and leads to female infertility

Alternative splicing(AS) contributes to gene diversification through RNA-binding proteins, but AS regulation during germline development remains largely undefined. Here, we report a comprehensive set of mRNA splicing events mediated by epithelial splicing regulatory proteins 1(Esrp1) to regulate mouse oocyte development. Collectively, our data highlights that ESRP1-mediated AS program are required for oocyte development and female fertility maintainance. Overall design: MII oocytes from 6-week-old WT and Esrp1-KO females. RNA profiling data form both groups was collected from four biological replicates.