ProteomeHD - Complete Co-Regulated Proteins Network

ProteomeHD is a database which documents the response of 10,323 human proteins to 294 biological perturbations, measured by isotope-labelling mass spectrometry. Using this data matrix and robust machine learning we create a co-regulation map of the cell that reflects functional associations between human proteins. The map identifies a functional context for many uncharacterized proteins, including microproteins that are difficult to study with traditional methods. Co-regulation also captures relationships between proteins which do not physically interact or co-localize.

For a description of how the scores were calculated and what cut-offs can be useful for downstream analyses, please refer to our paper.