Reactivation of herpesviruses promotes the disease progression and alters the respiratory microbiome in patients with pulmonary infection

The herpesviruses are able to establish colonizing and latency in the human body, posing a significant threat to the prognosis of patients. However, the impact of herpesviruses on the prognosis of individuals with pulmonary infections and the respiratory microbiota remains poorly understood. Here, we retrospectively analyzed respiratory samples from 100 patients with pulmonary infection (PI) detected by mNGS to evaluate the effect of herpesvirus activation on the pathogen spectrum and respiratory microecological of PI patients.