Transcriptomics of rhinovirus persistence reveals sustained expression of RIG-I and interferon-stimulated genes

The persistence of HRV RNA does not necessarily indicate an active infection during prolonged infection. The sustained expression of RIG-I, IFNs, chemokines, and ISGs in response to viral RNA persistence highlights the importance of assessing how immune-activating host factors change during an active HRV infection and the immune regulation that persists thereafter. Overall design: Genome-wide RNA sequencing