Heat shock transcription factor 1(HSF1) is an important transcription factor which regulates the expression of a wide array of genes including heat shock proteins and oncogenes. Here, we report that H
PC12 cells are a well-established model to study how differences in signal transduction duration can elicit distinct cell behaviors. Epidermal growth factor (EGF) activates transient ERK signaling in
c-Jun, a crucial component of the dimeric transcription factor activating protein 1 (AP-1), can regulate apoptosis induced by oxidative stress and has been implicated in neuronal differentiation, but
Purpose: WNT/CTNNB1 signaling promotes mammary tumor formation in mice, but the direct and immediate effects of elevated levels of WNT/CTNNB1 signaling on the mouse mammary epithelium remain unknown.
