Structure–Activity Relationship Studies of Retro‑1 Analogues against Shiga Toxin
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https://figshare.com/articles/dataset/Structure_Activity_Relationship_Studies_of_Retro_1_Analogues_against_Shiga_Toxin/12721545
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High-throughput screening has shown that Retro-1 inhibits ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus. To improve the activity of Retro-1, a structure–activity relationship (SAR) study was undertaken and yielded an analogue with a roughly 70-fold better half-maximal effective concentration (EC50) against Shiga toxin cytotoxicity measured in a cell protein synthesis assay.
创建时间：
2020-07-10
