Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 823.

Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 823. Descriptor: 4-methoxy-N-phenyl-3-({3-[(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)sulfanyl]propanoyl}amino)benzamide, serine/threonine kinase 6 Authors: Elling, R.A, Erlanson, D.A, Yang, W, Tangonan, B.T, Hansen, S.K, Romanowski, M.J. Deposit date: 2008-06-22 Release date: 2009-05-05 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: New fragment-based drug discovery To be Published

小鼠极光激酶A（Aurora-A）催化结构域（天冬酰胺186→甘氨酸、赖氨酸240→精氨酸、甲硫氨酸302→亮氨酸）与化合物823结合的晶体结构。配体描述：4-甲氧基-N-苯基-3-({3-[(1H-吡咯并[2,3-b]吡啶-5-基甲基)硫基]丙酰基}氨基)苯甲酰胺、丝氨酸/苏氨酸激酶6（serine/threonine kinase 6）。作者：Elling, R.A.、Erlanson, D.A.、Yang, W.、Tangonan, B.T.、Hansen, S.K.、Romanowski, M.J.。存档日期：2008-06-22，发布日期：2009-05-05，末次修改日期：2023-08-30。检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.7 Å。引用：《基于片段的药物发现》（New fragment-based drug discovery），待发表。