Time-resolved small angle X-ray scattering experiments (USAXS to WAXS) on new hybrid colloidal scaffolds from freeze-casting, used in mandib

Development of bio-composite scaffolds for osteoradionecrosis treatment will be addressed here from a new concept based on bioactive glass nanoparticles and the freeze-casting process. The proposal aims to shed light on the mechanisms involved on the colloidal assembly process starting from a solid/solution interface and using time-resolved small-angle X-ray scattering experiments at ID02/ESRF over a broad q-range (USAXS, SAXS and WAXS). We will study the structure and interactions of the elementary bricks (Hybrid bioglass and in-operando material formation, reaching macroscopic scaffold via freeze-casting from the solid/solution interface using a dedicated user supplied sample environment.

本研究将围绕基于生物活性玻璃纳米颗粒（bioactive glass nanoparticles）与冷冻铸造（freeze-casting）工艺的全新理念，开展用于放射性骨坏死（osteoradionecrosis）治疗的生物复合支架开发工作。本项目旨在阐明以固-液界面为起始的胶体组装过程所涉及的作用机制，实验将依托ID02/欧洲同步辐射光源（ESRF）线站的宽q范围时间分辨小角X射线散射（time-resolved small-angle X-ray scattering）测试系统展开，涵盖超小角X射线散射（USAXS）、小角X射线散射（SAXS）与广角X射线散射（WAXS）三类测试模式。我们将研究结构基元（混合生物活性玻璃）的结构与相互作用，并借助定制化用户供样环境舱，通过固-液界面的冷冻铸造工艺制备宏观支架，同时实现原位（in-operando）材料形成过程的表征。