Partial dataset related to the article "Clinical parameters of death and heart failure hospitalization in biventricular systolic dysfunction assessed via cardiac magnetic resonance"

This record contains raw data related to the article “Clinical parameters of death and heart failure hospitalization in biventricular systolic dysfunction assessed via cardiac magnetic resonance" Aims: While factors associated with adverse events are well elucidated in setting of isolated left ventricular dysfunction, clinical and imaging-based prognosticators of adverse outcomes are lacking in context of biventricular dysfunction. The purpose of this study was to establish role of clinical variables in prognosis of biventricular heart failure (HF), as assessed by cardiac magnetic resonance imaging.Methods: Study cohort consisted of 840 patients enrolled in DERIVATE registry with coexisting CMR-derived right ventricular (RV) and left ventricular (LV) dysfunction, as defined by RV and LV ejection fractions ≤45 % and ≤ 50 %, respectively. The primary objective was to identify factors associated with adverse long-term outcomes, defined as composite of all-cause death and HF hospitalizations (DHFH). Kaplan-Meir curves were plotted for survival analysis. Cox proportional hazard models were constructed to estimate adjusted hazard ratios (aHRs) and associated 95 % confidence intervals for clinical variables and their correlation with adverse events.Results: Mean age was 61.0 years; 83.1 % were male, 26.6 % had diabetes mellitus (DM), and 45.9 % had nonischemic cardiomyopathy. At median follow-up of 2 years, DHFH occurred in 32.5 % of the cohort. Kaplan-Meir analysis showed higher rate of DHFH in patients with DM (35.2 % vs. 22.6 %, p < 0.001). Multivariate Coxregression analysis showed that DM was independently associated with DHFH (aHR 1.61 [95 % CI: 1.15–2.25]; p = 0.003). Importantly, ACE-inhibitor/ARB usage in patients with DM was associated with significant reductionin DHFH (aHR 0.53 [95 % CI: 0.31–0.90]; p = 0.02).Conclusion: In patients with biventricular HF, DM was a strong predictor of DHFH, with ACE-inhibitor/ARB usage having cardioprotective effect.本数据集包含与题为《通过心脏磁共振成像评估的双心室收缩功能障碍患者的死亡与心力衰竭住院临床参数》的学术论文相关的原始数据。 研究背景：孤立性左心室功能异常相关不良事件的影响因素已得到充分阐明，但双心室功能异常患者不良预后的临床及影像学预测指标仍有待明确。本研究旨在明确临床变量在通过心脏磁共振成像（cardiac magnetic resonance, CMR）评估的双心室心力衰竭（biventricular heart failure, HF）预后中的作用。 方法：本研究队列纳入了DERIVATE注册研究中的840例患者，所有患者均存在经CMR证实的右心室（right ventricular, RV）及左心室（left ventricular, LV）功能异常，定义为RV射血分数≤45%、LV射血分数≤50%。本研究的主要目标为明确与长期不良结局相关的影响因素，长期不良结局定义为全因死亡与心力衰竭住院复合终点（all-cause death and HF hospitalizations, DHFH）。采用Kaplan-Meier曲线进行生存分析，构建Cox比例风险模型以估算临床变量的校正后风险比（adjusted hazard ratios, aHRs）及对应的95%置信区间（95% CI），并分析其与不良事件的相关性。 结果：本队列患者的平均年龄为61.0岁，其中男性占比83.1%，糖尿病（diabetes mellitus, DM）患者占比26.6%，非缺血性心肌病患者占比45.9%。中位随访2年时，队列中32.5%的患者发生了DHFH。Kaplan-Meier分析显示，糖尿病患者的DHFH发生率显著更高（35.2% vs. 22.6%，p<0.001）。多因素Cox回归分析显示，糖尿病是DHFH的独立相关因素（aHR 1.61，95% CI：1.15~2.25；p=0.003）。值得注意的是，糖尿病患者使用血管紧张素转换酶抑制剂（ACE-inhibitor）/血管紧张素Ⅱ受体拮抗剂（ARB）可显著降低DHFH发生风险（aHR 0.53，95% CI：0.31~0.90；p=0.02）。 结论：在双心室心力衰竭患者中，糖尿病是DHFH的强预测因子，而ACE-inhibitor/ARB的使用具有心脏保护作用。