Innate immune responses between low DIPs and high DIPs LAIV inoculations in the mouse upper respiratory tract revealed by bulk RNA-seq

To investigate the innate immune responses of low DIPs and high DIPs H3N2 LAIVs in mouse turbinate tissues, the transcriptomes at multiple timepoints were analyzed using bulk RNA-seq. Female 6–8-week-old BALB/c mice were intranasally immunized with of low DIPs LAIV or high DIPs LAIV. The turbinate and adjacent mucosal tissues were isolated at 8 hpi, 2 dpi, 4 dpi, and 6 dpi, respectively for bulk RNA-seq.