Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor
收藏Protein Data Bank Japan2024-04-03 更新2026-03-21 收录
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Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor Descriptor: N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase Authors: Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. Deposit date: 2008-02-26 Release date: 2009-03-03 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments. Bioorg.Med.Chem.Lett., 18, 2008
新型哒嗪酮类抑制剂与丙型肝炎病毒（HCV）NS5B聚合酶的晶体结构
描述符：N-{3-[5-羟基-2-(3-甲基丁基)-3-氧代-6-噻吩-2-基-2,3-二氢哒嗪-4-基]-1,1-二氧代-2H-1,2,4-苯并噻二嗪-7-基}甲磺酰胺，RNA依赖的RNA聚合酶
作者：Zhao, Q、Showalter, R.E、Han, Q、Kissinger, C.R.
提交日期：2008-02-26
发布日期：2009-03-03
最后修改日期：2024-04-03
测试方法：X射线衍射（分辨率2.1 Å）
引用文献：源自4-(1',1'-二氧代-1',4'-二氢-1'λ⁶-苯并[1',2',4']噻二嗪-3'-基)-5-羟基-2H-哒嗪-3-酮的新型HCV NS5B聚合酶抑制剂。第3部分：2-、6-及7'-位取代基的进一步优化与初步药代动力学评估。Bioorg.Med.Chem.Lett., 18, 2008
创建时间：
2008-02-26
