Dataset for Significant Metabolic Alterations in Mouse Dams Exposed to an Environmental Mixture of Polychlorinated Biphenyls (PCBs) During Gestation and Lactation: Insights into PCB and Metabolite Profiles

Polychlorinated biphenyls (PCBs) and their metabolites are linked to developmental neurotoxicity, but their levels in the gestational and lactational environment remain unexplored. This study investigated the effects of dietary exposure to the Fox River Mixture (FRM) on serum levels of PCBs and their metabolites in female C57BL/6J mice. The mice were exposed to 0, 0.1, 1, and 6 mg/kg body weight of FRM beginning two weeks before mating and throughout gestation and lactation. Serum samples from the dams were analyzed using gas chromatography-mass spectrometry (GC-MS/MS) and liquid chromatography-high resolution mass spectrometry (LC-HRMS). This dataset includes the data from the targeted analysis of PCBs and OH-PCBs by GC-MS-MS, untargeted analysis of polar PCB metabolites with negative mode LC-HRMS, the quality assurance and quality control data, and the corresponding raw data acquired by GC-MS-MS and LC-HRMS.