Phosphorylation-dependent membraneless organelle fusion and fission illustrated by postsynaptic density condensates

Fig 1 CaMKⅡα triggers the fusion of two immiscible PSD condensates. Fig 2 CaMKⅡα regulates the interaction between SAPAP and PSD-95. Fig 3 Phosphorylation on the GBR of GKAP is sufficient to achieve the fusion of two immiscible PSD condensates. Fig 4 Phosphorylation of multiple GBRs enhances phase separation of PSD proteins. Fig 5 A designed GKAP-DLS protein mimicking constitutively phosphorylated GKAP Fig 6 Phosphorylation of GBRs of SAPAPs is critical for synapse maturation in cultured neurons. Fig S3 Generation and characterization of Sapap3KO mice