EDEN2020 Human Brain MRI Datasets for Brain Glioma Patients

The datasets available in this folder regard the acquisition of high-resolution MRI images of a cohort of 30 brain glioma adult patients acquired on a 3 Tesla Philips scanner at the Neuroradiology Unit and CERMAC <em>(Center of Excellence for High Field Magnetic Resonance)</em>, Vita-Salute San Raffaele University and IRCCS Ospedale San Raffaele, Milano, Italy. The acquisition is carried out in the context of the EU’s Horizon EDEN2020 project as part of the work for <em>Deliverable D2.2 Human Brain Imaging Database</em>. Histopathological and molecular details of this cohort of patients are reported in the Patients' Table included in the <em>Readme.md</em> file. The data includes: 3D_FLAIR_Tra: Fluid‑Attenuated Inversion Recovery volumetric sequence acquired on the axial plane for morphological characterization of the lesion. raw_data_DTI_32: Diffusion Tensor Imaging raw data. This is a diffusion-weighted Spin Echo EPI single-shot pulse sequence acquired on the axial plane along 32 gradient directions at a b-value of 1000 s/mm² and one volume without diffusion-weighting (b0 image). Axial (AD), Radial (RD), Mean Diffusivity (MD) and Fractional Anisotropy maps derived from 'raw_data_DTI_32' sequence using the Philips IntelliSpace Portal software platform, version 8.0 (Philips Healthcare, Best, The Netherlands) and saved using the ‘_map_DTI_32_gray' suffix. raw_data_NODDI: multi-compartmental dMRI sequence for advanced tractography and NODDI analyses, including an axial high angular resolution diffusion-weighted imaging (HARDI) acquisition along 60 gradient directions at a b-value of 3000 s/mm²a DTI acquisition along 35 directions at a b-value of 711 s/mm² and 11 volumes without diffusion-weighting (b0 images). Phase-encoding direction was anterior-to-posterior for all these acquisitions. B0_reverse: a sequence without diffusion-weighting having the same geometrical parameters of the ‘raw_data_NODDI’ images,but acquired using a reversed phase-encoding direction (posterior-to-anterior). This volume allowed estimation and correction for susceptibility-induced distortions. SWI_axial: Susceptibility‑Weighted Imaging sequence acquired on the axial plane for detection of Intratumoral Susceptibility Signals (ITSS), microhemorrages and calcifications. Phase map and magnitude image are separated in two distinguished files, using the ‘_ph’ suffix for phase maps. s3DI_MC_HR: three-dimensional high-resolution time of flight (TOF) MR angiography acquisition to visualize flow within the arterial vessel. Post-gadolinium T1_3D_PROSET_Sag: T1-weighted volumetric sequence acquired on the sagittal plane for morphological characterization of the lesions and detection of areas of contrast enhancement. Note that all MRI data files were converted from DICOM series using Chris Rorden's dcm2niiX version v1.0.20200331.本文件夹内的数据集涵盖30例成人脑胶质瘤患者队列的高分辨率磁共振成像（Magnetic Resonance Imaging, MRI）采集数据，采集设备为意大利米兰圣拉斐尔生命健康大学（Vita-Salute San Raffaele University）及IRCCS圣拉斐尔医院神经放射科与CERMAC（高场磁共振卓越中心，Center of Excellence for High Field Magnetic Resonance）的3特斯拉飞利浦扫描仪。本数据集采集工作隶属于欧盟地平线计划旗下的EDEN2020项目，是交付件D2.2《人类脑成像数据库》相关研究工作的一部分。该队列患者的组织病理学与分子生物学详情，请参见Readme.md文件中收录的患者表格。 本数据集包含以下内容： 1. 3D_FLAIR_Tra：液体衰减反转恢复（Fluid-Attenuated Inversion Recovery, FLAIR）容积序列，于轴位平面采集，用于病灶的形态学表征。 2. raw_data_DTI_32：扩散张量成像（Diffusion Tensor Imaging, DTI）原始数据。该序列为扩散加权自旋回波平面回波单次激发脉冲序列，于轴位平面采集，沿32个梯度方向施加扩散敏感梯度，b值为1000 s/mm²，同时包含1幅无扩散加权的图像（b0图像）。 3. 基于raw_data_DTI_32序列衍生得到的轴向扩散系数（Axial Diffusivity, AD）、径向扩散系数（Radial Diffusivity, RD）、平均扩散系数（Mean Diffusivity, MD）与各向异性分数（Fractional Anisotropy, FA）图谱，采用飞利浦IntelliSpace Portal 8.0软件平台（荷兰飞利浦医疗保健公司，贝斯特市）生成，并以"_map_DTI_32_gray"作为后缀保存。 4. raw_data_NODDI：用于先进纤维束追踪与神经突方向分散密度成像（Neurite Orientation Dispersion and Density Imaging, NODDI）分析的多室扩散磁共振成像（diffusion magnetic resonance imaging, dMRI）序列，包含以下采集模块：沿60个梯度方向采集、b值为3000 s/mm²的轴位高角分辨率扩散加权成像（High Angular Resolution Diffusion-weighted Imaging, HARDI）；沿35个梯度方向采集、b值为711 s/mm²的DTI序列；以及11幅无扩散加权的图像（b0图像）。所有上述采集的相位编码方向均为从前到后。 5. B0_reverse：无扩散加权序列，其几何参数与raw_data_NODDI图像一致，但相位编码方向为反向（从后到前）。该序列可用于估算并校正磁化率诱导的图像畸变。 6. SWI_axial：磁敏感加权成像（Susceptibility-Weighted Imaging, SWI）序列，于轴位平面采集，用于检测瘤内磁敏感信号（Intratumoral Susceptibility Signals, ITSS）、微出血与钙化。相位图与幅值图像分为两个独立文件，相位图以"_ph"作为后缀命名。 7. s3DI_MC_HR：三维高分辨率飞行时间（Time of Flight, TOF）磁共振血管造影序列，用于显示动脉血管内的血流情况。 8. Post-gadolinium T1_3D_PROSET_Sag：钆剂增强T1加权容积序列，于矢状位平面采集，用于病灶的形态学表征与对比强化区域的检测。 请注意，所有MRI数据文件均由Chris Rorden开发的dcm2niiX v1.0.20200331版本从DICOM序列转换而来。