Physiological parameters for three farm animal species (cattle, sheep, and swine) as the basis for the development of generic physiologically based kinetic models

<strong>IMPORTANT : PLEASE DISREGARD VERSION 1 OF THIS UPLOAD SINCE IT INCLUDES ERRONEOUS INFORMATION.</strong> This excel file (DOI: 10.5281/zenodo.3433224) provides physiological parameters and their inter-individual variability (mean, coefficient of variation, sample size) for three farm animal species: cattle (<em>Bos taurus</em>), sheep (<em>Ovis aries</em>), and swine (<em>Sus scrofa domesticus</em>). These physiological parameters were estimated based on the results of extensive literature searches and specific experimental data described in Lautz et al., (2020). This file is associated with R codes (DOI: 10.5281/zenodo.3432796) for generic PBK models, partition coefficient Quantitative Structure Activity Relationship (QSAR) models for each farm animal species and parameterisation of the model. The full data collection and implementation of the models using case studies are described in Lautz et al., 2020 (10.1016/j.toxlet.2019.10.008).重要提示：请忽略本上传文件的版本1，因其包含错误信息。本Excel文件（DOI：10.5281/zenodo.3433224）提供了牛（*Bos taurus*）、绵羊（*Ovis aries*）及猪（*Sus scrofa domesticus*）三种农场动物的生理参数及其个体间变异数据，具体包括均值、变异系数与样本量。上述生理参数系基于大规模文献检索结果，以及Lautz等人（2020）中描述的专属实验数据估算得到。本文件与通用生理药代动力学（Physiologically Based Pharmacokinetic，PBK）模型、适配各农场动物物种的分配系数定量结构-活性关系（Quantitative Structure Activity Relationship，QSAR）模型，以及模型参数化所需的R代码（DOI：10.5281/zenodo.3432796）相关联。完整的数据收集工作以及通过案例研究实现模型的相关内容，详见Lautz等人2020年发表的研究成果（DOI：10.1016/j.toxlet.2019.10.008）。