Figure S1 - The DOCK Protein Sponge Binds to ELMO and Functions in Drosophila Embryonic CNS Development

Loss of Spg results in mild CNS defects. (A–E) Stage 16 embryos stained with FasII. (A, B) Both spg242 (A) and spg805 (B) over a deficiency that removes the spg locus result in mild gaps in the outer longitudinal fascicles (arrowheads). (C) The same phenotype are observed in animals trans-heterozygous for spg242 and spg805. (D, E) Knockdown of Spg by RNAi resulted in similar axonal outgrowth phenotypes (D) and bifurcated axons (asterisk in E). (EPS)