Human p38 MAP Kinase in Complex with Dibenzosuberone Compound 1

Human p38 MAP Kinase in Complex with Dibenzosuberone Compound 1 Descriptor: 3-[(3-benzamido-4-fluoranyl-phenyl)amino]-~{N}-(2-morpholin-4-ylethyl)-11-oxidanylidene-5,6-dihydrodibenzo[1,2-~{d}:1',2'-~{f}][7]annulene-9-carboxamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside Authors: Mayer-Wrangowski, S.C, Rauh, D. Deposit date: 2016-09-15 Release date: 2017-04-19 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Optimized Target Residence Time: Type I1/2 Inhibitors for p38 alpha MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine. Angew. Chem. Int. Ed. Engl., 56, 2017

与人二苯并卓酮类化合物1形成复合物的人p38丝裂原活化蛋白激酶（p38 MAP Kinase）的描述信息：配体为3-[(3-苯甲酰胺基-4-氟苯基)氨基]-N-(2-吗啉-4-基乙基)-11-氧代-5,6-二氢二苯并[1,2-d:1',2'-f][7]轮烯-9-甲酰胺，体系包含丝裂原活化蛋白激酶14（Mitogen-activated protein kinase 14）与辛基β-D-吡喃葡萄糖苷。作者：Mayer-Wrangowski S.C.、Rauh D. 提交日期：2016-09-15，发布日期：2017-04-19，最后修改日期：2024-05-08。实验方法：X射线衍射（分辨率2.1 Å）。引用文献：《通过直接与R骨架相互作用优化p38α丝裂原活化蛋白激酶I1/2型抑制剂的靶标驻留时间》，《Angew. Chem. Int. Ed. Engl.》，2017年，第56卷。