Molecularly predicting colorectal polyp outcome to guide surveillance for recurrence or malignancy

Identification of molecular features that predict the malignant potential of a polyp is a major clinical step in individualizing polyp patient management. Why does one polyp develop into cancer while another does not? Our first aim was to validate our original findings on differences between polyps based on transformation in an expanded and independent cohort of patients. Our next aim was to identify the molecular events that define the transition point of polyps to cancer based on the aggressiveness of the polyp (polyp outcome phenotype) to develop a cancer risk prediction model for polyps.