Comparison of individual methods for the single-point mutations in terms of Pearson correlation coefficient (RP) and root-mean-square error (RMSE) on the S645, S1131, S4169 and S8338 datasets.

The methods are evaluated by the split-by-structure cross-validation (SSCV), where ECOD is used in data split to avoid the complexes similar to the training data appearing in the test set. The dash sign indicates the results of the corresponding methods are not available. †: Results were obtained based on the released source code. ‡: Results were obtained via the released tool.