Data from: How to calculate the non­-synonymous to synonymous rate ratio of protein-coding genes under the Fisher­-Wright mutation­-selection framework

First principles of population genetics are used to obtain formulae relating the non-synonymous to synonymous substitution rate ratio to the selection coefficients acting at codon sites in protein-coding genes. Two theoretical cases are discussed and two examples from real data (a chloroplast gene and a virus polymerase) are given. The formulae give much insight into the dynamics of non-synonymous substitutions and may inform the development of methods to detect adaptive evolution.

本研究运用群体遗传学基本原理，推导出可将非同义替换率与同义替换率之比，与作用于蛋白质编码基因密码子位点的选择系数相关联的公式。文中探讨了两种理论情形，并给出两个真实数据实例（一个叶绿体基因与一个病毒聚合酶基因）。该系列公式可显著增进对非同义替换动力学机制的理解，同时可为适应性进化检测方法的开发提供理论参考。