S.aureus TMK in complex with the potent inhibitor compound 38, 2-(3-CHLOROPHENOXY)-3-METHOXY-4-{(1R)-1-[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]PROPYL}BENZOIC ACID

S.aureus TMK in complex with the potent inhibitor compound 38, 2-(3-CHLOROPHENOXY)-3-METHOXY-4-{(1R)-1-[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]PROPYL}BENZOIC ACID Descriptor: 2-(3-chlorophenoxy)-3-methoxy-4-{(1R)-1-[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]propyl}benzoic acid, Thymidylate kinase Authors: Olivier, N.B. Deposit date: 2014-05-22 Release date: 2014-06-11 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Antibacterial inhibitors of gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region. J.Med.Chem., 57, 2014

与强效抑制剂化合物38（即2-(3-氯苯氧基)-3-甲氧基-4-{(1R)-1-[(3S)-3-(5-甲基-2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)哌啶-1-基]丙基}苯甲酸）形成复合物的金黄色葡萄球菌（Staphylococcus aureus）胸苷酸激酶（Thymidylate kinase, TMK）。描述：2-(3-氯苯氧基)-3-甲氧基-4-{(1R)-1-[(3S)-3-(5-甲基-2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)哌啶-1-基]丙基}苯甲酸。作者：奥利弗（Olivier, N.B.）。提交日期：2014-05-22。发布日期：2014-06-11。最后更新：2024-02-28。实验方法：X射线衍射（1.83 Å）。引用文献：《革兰氏阳性菌胸苷酸激酶的抗菌抑制剂：构效关系及新型疏水结合区域的手性偏好》，《J. Med. Chem.》，第57卷，2014年