Diastereoselective Synthesis of Biheterocyclic Tetrahydrothiophene Derivatives via Base-Catalyzed Cascade Michael-Aldol [3 + 2] Annulation of 1,4-Dithiane-2,5-diol with Maleimides
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https://figshare.com/articles/dataset/Diastereoselective_Synthesis_of_Biheterocyclic_Tetrahydrothiophene_Derivatives_via_Base_Catalyzed_Cascade_Michael_Aldol_3_2_Annulation_of_1_4_Dithiane_2_5_diol_with_Maleimides/2153227
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资源简介：
A highly diastereoselective intermolecular
[3 + 2] annulation of
1,4-dithiane-2,5-diol to maleimides has been developed by using DABCO
as a catalyst, which provides a series of highly functionalized biheterocyclic
tetrahydrothiophene derivatives containing tetrahydrothiophene and
pyrolidine backbones in excellent yields and diastereoselectivities
(up to 98% yield and >20:1 d.r.). The cascade Michael-aldol reaction
is capable of tolerating organic solvents as well as water.
创建时间：
2016-02-13
