Despite extensive research, our understanding of the rules according to which cis-regulatory sequences are converted into gene expression is limited We devised a method for obtaining parallel, highly
This file contains the source data for Extended Data Figure 1c. c, Hi-C matrix (at 5 kb resolution) and loops at the MRR1 region showing two looping silencers (S1 and S2) that exhibit chromatin intera
The critical process in development, bifurcation of cellular fates, requires epigenetic H3K27me3 marks propagated by PRC2 complex. However, the precise chromatin loci of functional H3K27me3 marks are
A protocol for performing the 4C library and the analysis in mice macrophages. We used the ChIP-seq data to mark the DNA element regions (Silencer) and used the 4C-seq technique to investigate all the
